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Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal sepsis and meningitis. In this study, we determined antibody-mediated deposition of complement C3b/iC3b onto the bacterial cell surface of GBS serotypes Ia, Ib, II, III, and V. This was determined for 520 mother and umbilical cord serum sample pairs obtained at the time of birth from a population on the Thailand-Myanmar border. Antibody-mediated deposition of complement C3b/iC3b was detected to at least one serotype in 91% of mothers, despite a known carriage rate in this population of only 12%. Antibody-mediated C3b/iC3b deposition corresponded to known carriage rates, with the highest levels of complement deposition observed onto the most prevalent serotype (serotype II) followed by serotypes Ia, III, V, and Ib. Finally, neonates born to mothers carrying serotype II GBS at the time of birth showed higher antibody-mediated C3b/iC3b deposition against serotype II GBS than neonates born to mothers with no serotype II carriage. Assessment of antibody-mediated C3b/iC3b deposition against GBS may provide insights into the seroepidemiology of anti-GBS antibodies in mothers and infants in different populations.

Original publication

DOI

10.1128/CVI.00803-14

Type

Journal article

Journal

Clin Vaccine Immunol

Publication Date

03/2015

Volume

22

Pages

319 - 326

Keywords

Antibodies, Bacterial, Carrier State, Complement C3b, Female, Flow Cytometry, Humans, Infant, Newborn, Matched-Pair Analysis, Mothers, Myanmar, Protein Binding, Refugees, Seroepidemiologic Studies, Serotyping, Streptococcal Infections, Streptococcus agalactiae, Thailand