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Subject-specific, or personalised, modelling is one of the main targets in current cardiac modelling research. The aim of this study is to assess the improvement in predictive power gained by introducing subject-specific fibre models within an electromechanical model of left ventricular contraction in rat. A quantitative comparison of a series of global rule-based fibre models with an image-based locally optimised fibre model was performed. Our results show small difference in the predicted values of ejection fraction, wall thickening and base-to-apex shortening between the fibre models considered. In comparison, much larger differences appear between predicted values and those measured in experimental images. Further study of the constitutive behaviour and architecture of cardiac tissue is required before electromechanical models can fully benefit from the introduction of subject-specific fibres. Additionally, our study shows that, in the current model, an orthotropic description of the tissue is preferable to a transversely isotropic one, for the metrics considered. © 2013 Springer-Verlag.

Original publication

DOI

10.1007/978-3-642-38899-6_6

Type

Journal article

Journal

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Publication Date

11/07/2013

Volume

7945 LNCS

Pages

46 - 53