Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.

Original publication

DOI

10.1038/ng.2653

Type

Journal article

Journal

Nat Genet

Publication Date

06/2013

Volume

45

Pages

580 - 585

Keywords

Consensus Development Conferences, NIH as Topic, Gene Expression, Gene Expression Profiling, Genome-Wide Association Study, Government Programs, Humans, Molecular Sequence Annotation, Organ Specificity, Quantitative Trait Loci, Tissue Banks, United States