Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable (CD95(+) Bcl-2(-)) CD4(+) and CD8(+) T cells increased substantially during acute CMV infection. The frequency of activated CD4(+) T cells was strongly associated with both concurrent CMV coinfection (P = 0.001) and HIV-1 viral load (P = 0.05). The frequency of apoptosis-vulnerable cells was also associated with CMV coinfection in the CD4 (P = 0.02) and CD8 (P < 0.001) T cell subsets. Similar observations were made in HIV-exposed uninfected infants. CMV-induced increases in T cell activation and apoptosis may contribute to the rapid disease progression in coinfected infants.

Original publication




Journal article


J Virol

Publication Date





11373 - 11379


ADP-ribosyl Cyclase 1, Apoptosis, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Coinfection, Cytomegalovirus, Cytomegalovirus Infections, Disease Progression, HIV Infections, HIV-1, HLA-DR Antigens, Humans, Infant, Kenya, Lymphocyte Activation, Proto-Oncogene Proteins c-bcl-2, Viral Load, fas Receptor