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Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable (CD95(+) Bcl-2(-)) CD4(+) and CD8(+) T cells increased substantially during acute CMV infection. The frequency of activated CD4(+) T cells was strongly associated with both concurrent CMV coinfection (P = 0.001) and HIV-1 viral load (P = 0.05). The frequency of apoptosis-vulnerable cells was also associated with CMV coinfection in the CD4 (P = 0.02) and CD8 (P < 0.001) T cell subsets. Similar observations were made in HIV-exposed uninfected infants. CMV-induced increases in T cell activation and apoptosis may contribute to the rapid disease progression in coinfected infants.

Original publication

DOI

10.1128/JVI.00790-12

Type

Journal article

Journal

J Virol

Publication Date

10/2012

Volume

86

Pages

11373 - 11379

Keywords

ADP-ribosyl Cyclase 1, Apoptosis, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Coinfection, Cytomegalovirus, Cytomegalovirus Infections, Disease Progression, HIV Infections, HIV-1, HLA-DR Antigens, Humans, Infant, Kenya, Lymphocyte Activation, Proto-Oncogene Proteins c-bcl-2, Viral Load, fas Receptor