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Recent findings of gene fusions in carcinomas recapitulate the discovery of chromosomal abnormalities in leukemias and sarcomas decades ago. A recurring feature of carcinoma gene fusions, in contrast to those in hematopoietic and mesenchymal malignancies, is that they result in aberrant cell signaling. This may reflect differences in the differentiation programs of these tissues.

Original publication

DOI

10.1016/j.cell.2009.04.034

Type

Journal article

Journal

Cell

Publication Date

01/05/2009

Volume

137

Pages

391 - 395

Keywords

Animals, Breast Neoplasms, Chromosome Aberrations, Female, Humans, Lung Neoplasms, Male, Neoplasms, Oncogene Fusion, Oncogene Proteins, Fusion, Prostatic Neoplasms