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Recent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compared patients with type 2 diabetes (n=992) with two independent control groups (n=536, n=1029) from the UK, and saw no difference in the frequency of the 16184-16193 poly-C tract. This finding was confirmed by a meta-analysis of European studies of 1455 patients and 3132 controls (odds ratio 1.16, 95% CI 0.94-1.44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes.

Original publication

DOI

10.1016/S0140-6736(05)67492-2

Type

Journal article

Journal

Lancet

Publication Date

05/11/2005

Volume

366

Pages

1650 - 1651

Keywords

DNA, Mitochondrial, Diabetes Mellitus, Type 2, Humans, Meta-Analysis as Topic, Poly C