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The activation of resting dendritic cells (DCs) is a crucial step in the initiation of adaptive immunity because it links peripheral events initiated by the encounter with pathogens to the activation and expansion of antigen-specific T lymphocytes in secondary lymphoid organs. It is well recognized that a wide variety of microbial products and endogenous signals can trigger DC activation, and that different DC subsets are specialized in inducing different classes of immune responses. In this review, we will focus on how different aspects of DC maturation are regulated not only by the nature of the DC maturation stimuli, but also by their duration, combination and timing, and provide an overview of how different modes of DC activation can affect T cell responses.

Original publication

DOI

10.1016/j.it.2007.03.008

Type

Journal article

Journal

Trends Immunol

Publication Date

05/2007

Volume

28

Pages

227 - 233

Keywords

Animals, Antigen Presentation, Cell Differentiation, Dendritic Cells, Humans, Lymphocyte Activation, Models, Biological, Signal Transduction, T-Lymphocytes, Time Factors, Toll-Like Receptors