Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Post-translational modifications of proteins occur very frequently. One of these modifications, citrullination, is the result of arginine deimination operated by an enzyme, peptidylarginine deiminase (PAD), whose activity is under strict genetic control. Serum antibodies reactive with citrullinated proteins/peptides are a very sensitive and specific marker for rheumatoid arthritis. Genes encoding for PAD enzymes have been investigated in RA: the PADI4 gene confers susceptibility to RA in Japanese patients, but not in Caucasians.

Original publication

DOI

10.1016/j.autrev.2005.04.007

Type

Journal article

Journal

Autoimmun Rev

Publication Date

11/2005

Volume

4

Pages

561 - 564

Keywords

Animals, Arthritis, Rheumatoid, Autoimmune Diseases, Citrulline, Fibrin, Humans, Hydrolases, Protein-Arginine Deiminases