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The past five years have seen many scientific and biological discoveries made through the experimental design of genome-wide association studies (GWASs). These studies were aimed at detecting variants at genomic loci that are associated with complex traits in the population and, in particular, at detecting associations between common single-nucleotide polymorphisms (SNPs) and common diseases such as heart disease, diabetes, auto-immune diseases, and psychiatric disorders. We start by giving a number of quotes from scientists and journalists about perceived problems with GWASs. We will then briefly give the history of GWASs and focus on the discoveries made through this experimental design, what those discoveries tell us and do not tell us about the genetics and biology of complex traits, and what immediate utility has come out of these studies. Rather than giving an exhaustive review of all reported findings for all diseases and other complex traits, we focus on the results for auto-immune diseases and metabolic diseases. We return to the perceived failure or disappointment about GWASs in the concluding section.

Original publication

DOI

10.1016/j.ajhg.2011.11.029

Type

Journal article

Journal

Am J Hum Genet

Publication Date

13/01/2012

Volume

90

Pages

7 - 24

Keywords

Autoimmune Diseases, Female, Genetic Linkage, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, History, 21st Century, Humans, Male, Metabolic Diseases, Translational Medical Research