Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The aetiology of Polycystic Ovary Syndrome (PCOS) is complex and multifactorial. There is much evidence, however, to suggest that adipose tissue plays an important role in the development and maintenance of PCOS pathology. There is a close correlation between adiposity and symptom severity in women with PCOS, and even modest reductions in weight generally translate into significant improvements in menstrual regularity, fertility and hyperandrogenic features. This review article considers the various mechanisms that might underlie this link between excess adiposity and PCOS - including the effects of differential insulin sensitivity, abnormal steroid hormone metabolism and adipocytokine secretion. Greater attention to the therapeutic options available to reduce the impact of excess adiposity on ovarian and metabolic function is essential to the management of PCOS.

Original publication

DOI

10.1111/j.1365-2265.2006.02587.x

Type

Journal article

Journal

Clin Endocrinol (Oxf)

Publication Date

08/2006

Volume

65

Pages

137 - 145

Keywords

Adipocytes, Adult, Androgens, Appetite Regulation, Cytokines, Estrogens, Female, Humans, Insulin Resistance, Lipid Metabolism, Obesity, Polycystic Ovary Syndrome