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We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).

Original publication

DOI

10.1038/ng.301

Type

Journal article

Journal

Nat Genet

Publication Date

02/2009

Volume

41

Pages

157 - 159

Keywords

Adult, Age of Onset, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Carrier Proteins, Case-Control Studies, Child, Europe, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Membrane Glycoproteins, Obesity, Morbid, Polymorphism, Single Nucleotide, Population, Proteins, Proto-Oncogene Proteins c-maf, Quantitative Trait Loci, Receptor, Melanocortin, Type 4, Risk Factors