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HIV-1-specific CD8 + T cells are present in most HIV-1-infected people and play an important role in controlling viral replication, but the characteristics of an effective HIV-specific T-cell response are largely unknown. The majority of HIV-2-infected people behave as long-term non-progressors while those who progress to AIDS do so in a manner indistinguishable from HIV-1. A detailed study of HIV-2 infection may identify protective immune responses. Robust gag p26-specific T-cell responses are elicited during HIV-2 infection and correlate with control of viremia. In this study, we analyzed features of an HLA-B*3501-restricted T-cell response to HIV-2 p26 that may contribute to virus control. In contrast to HIV-1, HIV-2-specific T cells are at an early stage of differentiation (CD27 + CD28 + ), a finding that relates directly to CD4 + T-cell levels and inversely to immune activation. The cells demonstrate IFN-γ secretion, oligoclonal T-cell receptor Vβ gene segment usage, exceptional avidity and secretion of pro-inflammatory cytokines. Despite the potentially strong selection pressure imposed on the virus by these cells, there was no evidence of HIV-2 sequence evolution. We propose that in chronic HIV-2 infection, the maintenance of early-differentiated, highly avid CD8 + T cells could account for the nonprogressive course of disease. Such responses may be desirable from an HIV vaccine. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

Original publication

DOI

10.1002/eji.200940295

Type

Journal article

Journal

European Journal of Immunology

Publication Date

01/01/2010

Volume

40

Pages

1963 - 1972