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Genome wide association analyses have revealed large numbers of common variants influencing predisposition to type 2 diabetes and related phenotypes. These studies have predominantly featured European populations, but are now being extended to samples from a wider range of ethnic groups. The transethnic analysis of association data is already providing insights into the genetic, molecular and biological causes of diabetes, and the relevance of such studies will increase as human discovery genetics increasingly moves towards sequencing-based approaches and a focus on low frequency and rare variants.

Original publication

DOI

10.4093/dmj.2011.35.2.91

Type

Journal article

Journal

Diabetes Metab J

Publication Date

04/2011

Volume

35

Pages

91 - 100

Keywords

Diabetes mellitus, type 2, Fine-mapping, Genetics, Genome-wide association, Multiethnic, Resequencing, Transethnic