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The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particular focus on the regulation of cellular excitability and exocytosis. We examine in turn: (i) the generation of metabolic signalling molecules; (ii) the regulation of beta-cell membrane potential; and (iii) insulin granule dynamics and exocytosis. We further discuss the role of well known and putative candidate metabolic signals as regulators of insulin secretion.

Original publication




Conference paper

Publication Date





2211 - 2225


Acyl Coenzyme A, Adenosine Triphosphate, Calcium Channels, Exocytosis, Glucose, Glycolysis, Humans, Insulin, Insulin-Secreting Cells, Membrane Potentials, Mitochondria, Models, Biological, NADP, Potassium Channels, Signal Transduction