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Infant monkeys have been subjected to hypoxia with an arterial pO2 of 20-22 Torr for 30 min. Following perfusion 1-2 weeks later electron microscopy of the motor cortex shows a selective degeneration of axon terminals making symmetrical synapses and which probably arise from inhibitory GABAergic interneurons. It is suggested that this may be related to the development of epilepsy following hypoxia.

Original publication

DOI

10.1016/0006-8993(80)90356-x

Type

Journal article

Journal

Brain research

Publication Date

09/1980

Volume

198

Pages

204 - 209

Keywords

Motor Cortex, Interneurons, Axons, Synapses, Animals, Macaca mulatta, Seizures, Nerve Degeneration, Hypoxia