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BackgroundEvidence on the risk of cardiovascular disease (CVD) and CVD risk factors in people with human immunodeficiency virus (PWH) is limited. We aimed to identify the risk of composite CVD, individual CVD events, and common risk factors.MethodsThis was a nationwide, population-based, cohort study comparing adult (≥18 years old) PWH with people without human immunodeficiency virus (HIV) matched on age, sex, ethnicity, and location. The primary outcome was composite CVD comprising stroke, myocardial infarction, peripheral vascular disease, ischemic heart disease, and heart failure. The secondary outcomes were individual CVD events, hypertension, diabetes, chronic kidney disease (CKD), and all-cause mortality. Cox proportional hazard regression models were used to examine the risk of each outcome.ResultsWe identified 9233 PWH and matched them with 35 721 HIV-negative individuals. An increased risk was found for composite CVD (adjusted hazard ratio [aHR], 1.50; 95% confidence interval [CI], 1.28-1.77), stroke (aHR, 1.42; 95% CI, 1.08-1.86), ischemic heart disease (aHR, 1.55; 95% CI, 1.24-1.94), hypertension (aHR, 1.37; 95% CI, 1.23-1.53), type 2 diabetes (aHR, 1.28; 95% CI, 1.09-1.50), CKD (aHR, 2.42; 95% CI, 1.98-2.94), and all-cause mortality (aHR, 2.84; 95% CI, 2.48-3.25).ConclusionsPWH have a heightened risk for CVD and common CVD risk factors, reinforcing the importance for regular screening for such conditions.

Original publication

DOI

10.1093/infdis/jiab420

Type

Conference paper

Publication Date

04/2022

Volume

225

Pages

1348 - 1356

Addresses

Institute for Applied Health Research, University of Birmingham, Birmingham, United Kingdom.

Keywords

Humans, HIV, HIV Infections, Cardiovascular Diseases, Myocardial Infarction, Hypertension, Diabetes Mellitus, Type 2, Incidence, Risk Factors, Cohort Studies, Adolescent, Adult, Female, Male, Renal Insufficiency, Chronic, Stroke, United Kingdom