Myocardial work and left ventricular mechanical adaptations following isometric exercise training in hypertensive patients.

O'Driscoll JM., Edwards JJ., Wiles JD., Taylor KA., Leeson P., Sharma R.

PURPOSE: Hypertension is a major risk factor for cardiovascular disease. Isometric exercise training (IET) reduces resting and ambulatory blood pressure; however, few studies have investigated the myocardial adaptations following IET. METHODS: We randomly assigned 24 unmedicated hypertensive patients in a cross-over study design to 4-weeks of IET and control period, separated by a 3-week washout period. Speckle tracking echocardiography was used to measure left ventricular (LV) mechanics, and global myocardial work indices were derived from non-invasive LV pressure-strain loops constructed from global longitudinal strain (GLS) indexed to brachial systolic blood pressure. RESULTS: IET significantly improved GLS (- 2.3 ± 2%, p 

DOI

10.1007/s00421-021-04882-3

Type

Journal article

Journal

Eur J Appl Physiol

Publication Date

30/01/2022

Keywords

Cardiac mechanics, Hypertension, Isometric exercise training, Myocardial work

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