Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The biochemical properties of the HLA-C antigen differ substantially from those of HLA-A and -B molecules. For this reason, HLA-C diversity and expression at the cell surface are much lower than its counterparts and in consequence HLA-C-restricted responses have been infrequently detected and described. In this review we summarise the key differences between HLA-C and other class I molecules and provide an update on natural killer and T-cell responses restricted by HLA-C. We also discuss the different clinical settings associated with HLA-C alleles which mainly consist of autoimmune disorders, cancers and chronic infections.

Original publication

DOI

10.1111/j.1365-2567.2011.03422.x

Type

Journal article

Journal

Immunology

Publication Date

05/2011

Volume

133

Pages

1 - 7

Keywords

Animals, HLA-C Antigens, Humans, Killer Cells, Natural, Lymphocyte Activation, T-Lymphocytes