The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.

Muskens IS., Li S., Jackson T., Elliot N., Hansen HM., Myint SS., Pandey P., Schraw JM., Roy R., Anguiano J., Goudevenou K., Siegmund KD., Lupo PJ., de Bruijn MFTR., Walsh KM., Vyas P., Ma X., Roy A., Roberts I., Wiemels JL., de Smith AJ.

Down syndrome is associated with genome-wide perturbation of gene expression, which may be mediated by epigenetic changes. We perform an epigenome-wide association study on neonatal bloodspots comparing 196 newborns with Down syndrome and 439 newborns without Down syndrome, adjusting for cell-type heterogeneity, which identifies 652 epigenome-wide significant CpGs (P 

DOI

10.1038/s41467-021-21064-z

Type

Journal

Nat Commun

Publication Date

05/02/2021

Volume

12

Keywords

Case-Control Studies, Core Binding Factor Alpha 2 Subunit, CpG Islands, DNA Methylation, Down Syndrome, Epigenesis, Genetic, Female, Fetus, GATA1 Transcription Factor, Genome, Human, Genome-Wide Association Study, Hematopoiesis, Hematopoietic Stem Cells, Humans, Infant, Newborn, Liver, Male, Promoter Regions, Genetic, Proto-Oncogene Protein c-fli-1

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