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Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular homeostasis. These attributes reflect the complex interactions between cell-intrinsic factors such as genomic-transcriptomic regulation and cell-extrinsic influences, including growth factor and nutrient availability. Alongside glucose and amino acid metabolism, fatty acid metabolism supports tumorigenesis and disease progression through a range of processes including membrane biosynthesis, energy storage and production, and generation of signaling intermediates. Here, we highlight the complexity of cellular fatty acid metabolism in cancer, the various inputs and outputs of the intracellular free fatty acid pool, and the numerous ways that these pathways influence disease behavior.

Original publication

DOI

10.1186/s40170-020-00237-2

Type

Journal article

Journal

Cancer Metab

Publication Date

07/01/2021

Volume

9

Keywords

Cellular membrane, De novo synthesis, Fatty acid, Lipid, Lipid droplets, Mitochondria, Oxidation, Peroxisome