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In the TOURMALINE-MM3 study, post-autologous stem cell transplantation maintenance therapy with the oral proteasome inhibitor ixazomib versus placebo significantly improved progression-free survival (PFS), with a favorable safety profile. With ixazomib versus placebo maintenance, deepening responses occurred in 139/302 (46%) versus 60/187 (32%) patients with very good partial response or partial response (VGPR/PR) at study entry (relative risk 1.41, P = 0.004), and median time to best confirmed deepened response was 19.9 versus 30.8 months (24-month rate: 54.2 versus 41.4%; hazard ratio (HR): 1.384; P = 0.0342). Median PFS in patients with VGPR/PR at study entry was 26.2 versus 18.5 months (HR: 0.636, P 

Original publication




Journal article



Publication Date





3019 - 3027


Adult, Aged, Antineoplastic Agents, Boron Compounds, Combined Modality Therapy, Female, Glycine, Hematopoietic Stem Cell Transplantation, Humans, Kaplan-Meier Estimate, Maintenance Chemotherapy, Male, Middle Aged, Multiple Myeloma, Neoplasm Staging, Postoperative Care, Treatment Outcome, Young Adult