Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Objective: To investigate the relationship between white matter lesions (WML) within the cholinergic pathway and vascular cognitive impairment. Method: Middle-aged and elderly stroke patients underwent brain MRI examination and Montreal Cognitive Assessment (MoCA). Cholinergic Pathways Hyperintensities Scale (CHIPS) scores and the overall WML burden by Schelten on fluid-attenuated inversion recovery MRI images were determined and compared with MoCA scores. Spearman partial rank correlation coefficients and standardized regression coefficients were calculated. Results: Thirty four patients were included (mean age (62.2 ± 8.8) years, 45-82 years). MoCA scores negatively correlated with WML burdens by Schelten scores (β=-0.357, P=0.042) and CHIPS scores (β=-0.382, P=0.026). CHIPS scores were negatively associated with visuospatial and executive function (r=-0.290, P=0.048), naming function (r=-0.486, P=0.002), attention (r=-0.311, P=0.037) and abstraction (r=-0.344, P=0.023). Schelten scores were negatively associated with naming function (r=-0.492, P=0.002), attention (r=-0.364, P=0.017) and abstraction (r=-0.390, P=0.011). Conclusion: WML lesions within the cholinergic pathyway play a possible role in vascular cognitive impairment especially in visuospatial and executive function.

Original publication

DOI

10.3760/cma.j.issn.1006-7876.2010.09.004

Type

Journal article

Journal

Chinese Journal of Neurology

Publication Date

01/09/2010

Volume

43

Pages

612 - 616