Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).

Original publication

DOI

10.1038/ng.2007.32

Type

Journal article

Journal

Nat Genet

Publication Date

12/2007

Volume

39

Pages

1431 - 1433

Keywords

Arthritis, Rheumatoid, Chromosomes, Human, Pair 6, Female, Genetic Predisposition to Disease, Genome, Human, Humans, Linkage Disequilibrium, Male, Polymorphism, Single Nucleotide, Protein Tyrosine Phosphatase, Non-Receptor Type 22