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Notch signaling is essential for hematopoietic stem cell (HSC) formation during embryogenesis, and hitherto it was also thought to be required for HSC maintenance. However, in this issue of Cell Stem Cell, Maillard et al. (2008) demonstrate rather conclusively that inactivation of the Notch pathway in HSCs does not interfere with their self-renewal.

Original publication

DOI

10.1016/j.stem.2008.03.016

Type

Journal article

Journal

Cell Stem Cell

Publication Date

10/04/2008

Volume

2

Pages

293 - 294

Keywords

Animals, Cell Proliferation, Hematopoietic Stem Cells, Humans, Receptors, Notch, Signal Transduction