Darunavir concentrations exceed the protein-corrected EC<inf>50</inf> for wild-type HIV in the semen of HIV-1-infected men
Taylor S., Jayasuriya AN., Berry A., Gilleran G., Dufty NE., Else L., Back DJ., Smit EJ.
Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC50 values for wild-type HIV-1. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.