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Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC50 values for wild-type HIV-1. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Original publication

DOI

10.1097/QAD.0b013e32833ead18

Type

Journal article

Journal

AIDS

Publication Date

23/10/2010

Volume

24

Pages

2583 - 2586