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In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.

Original publication

DOI

10.1097/00002030-200208160-00016

Type

Journal article

Journal

AIDS

Publication Date

16/08/2002

Volume

16

Pages

1684 - 1686