Little is known about the inflammasome beyond its function in innate immune response. In this issue of Immunity, Tyrkalska et al. report that the inflammasome regulates the balance between erythroid and myeloid differentiation in model systems, providing insights into hematopoietic lineage bias associated with inflammatory conditions.
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GATA1 Transcription Factor, Hematopoiesis, Immunity, Innate, Inflammasomes, NLR Family, Pyrin Domain-Containing 3 Protein