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C-type cytochromes are proteins that are essential for the life of virtually all organisms. They characteristically contain heme that is covalently attached via thioether bonds to two cysteines in the protein. In this Account, we describe the challenging chemistry of thioether bond formation and the surprising variety of biogenesis systems that exist in nature to perform the difficult posttranslational heme attachment process. We show what insight has been gained into the various biogenesis systems from in vitro and in vivo experiments and highlight some forthcoming challenges in this field.

Original publication

DOI

10.1021/ar030266l

Type

Journal article

Journal

Acc Chem Res

Publication Date

12/2004

Volume

37

Pages

999 - 1007

Keywords

Animals, Bacterial Proteins, Cytochromes c, Heme, Mitochondria, Models, Molecular, Molecular Structure