My current research is focused on using large-scale genetic data such as T2D-GENES /GoT2D/DIAGRAM Consortium, UK Biobank and China Kadoorie Biobank obtained from next-generation sequencing and GWAS approaches to 1) identify and characterise genetic variants influencing predisposition to type 2 diabetes and its related traits; 2) investigate the causal relationship between an exposure or intermediate phenotype and type 2 diabetes/cardiovascular diseases using Mendelian randomisation approaches; 3) identify genetic factors contributing to weight loss after bariatric surgery procedures.
I received my Ph.D degree at the Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. In 2014, I joined Professor Mark McCarthy's group as postdoc researcher. I'm now also collaborating with Prof Rachel Batterham at UCLH and Professor Zhengming Chen at CTSU, Oxford University.
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
Justice AE. et al, (2019), Nat Genet, 51, 452 - 469
Inverse relationship between coarse food grain intake and blood pressure among young Chinese adults.
Liu X. et al, (2018), Am J Hypertens
Cannabis use and risk of schizophrenia: a Mendelian randomization study.
Vaucher J. et al, (2018), Mol Psychiatry, 23, 1287 - 1292
Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank.
Gan W. et al, (2016), Diabetologia, 59, 1446 - 1457
Rare and low-frequency coding variants alter human adult height.
Marouli E. et al, Nature, 542, 186 - 190