- Thakker Group: Academic Endocrine Unit Research Group
BA (Hons); MA (Cantab); MB BChir; MRCP
Clinical Research Fellow
I was awarded a Wellcome Trust Clinical Research Training Fellowship in 2016 for my DPhil project entitled 'The Role of the Adaptor Protein-2 Sigma Subunit in Calcium Homeostasis'. This work explores the biology of G-Protein Coupled Receptor (GPCR) function, focusing on the calcium sensing receptor (CaSR). Loss-of-function and gain-of-function mutations to the CaSR result in hypercalcaemia and hypocalcaemia, relevant to my background as a Specialist Registrar in Diabetes and Endocrinology, and are associated with osteoporosis, kidney stones, epilepsy and neurocognitive problems. I am studying the CaSR signalling pathway and its components, focusing on the role of adaptor protein 2 sigma subunit which is involved in clathrin mediated endocytosis of the CaSR as mutations of this gives rise to hypercalcaemia.
Prior to starting my fellowship I graduated from the University of Cambridge with an intercalated BA in Pathology (2004), MB BChir (2007) and MA (Cantab) (2008). I completed my general professional training (MRCP) in 2010 and my specialty specific examination (SCE) in 2013. On completion of this DPhil I hope to continue to combine scientific research with clinical work with an ultimate aim of becoming an academic endocrinologist.