Fluid shear stress plays a key role in sculpting blood vessels during development, in adult vascular homeostasis and in vascular pathologies. During evolution, endothelial cells evolved several mechanosensors that convert physical forces into biochemical signals, a process termed mechanotransduction. This Review discusses our understanding of endothelial flow sensing and suggests important questions for future investigation.
Journal article
2023-06-01T00:00:00+00:00
2
517 - 529
12
Humans, Mechanotransduction, Cellular, Animals, Endothelial Cells, Stress, Mechanical, Endothelium, Vascular, Regional Blood Flow