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Receptor dynamics and the cytokeleton
I am a scientist with expertise in immunology, cell biology, imaging, and image analysis. My aim is to investigate membrane receptor dynamics and its role in mediating ligand interactions. Specifically, I work on LYVE-1, a crucial receptor for hyaluronan, exclusively expressed on lymphatic endothelial cells and lymph node synapses. Changes in the spatial organisation of the cell surface receptors, such as clustering of proteins, often lead to the triggering of signalling events that contribute to changes in effector or cellular functions. A key player involved in this mechanism is the cytoskeleton and membrane lipids. In this project, I investigate the interactions of LYVE-1 with the actin cytoskeleton and membrane in mediating hyaluronan interactions. I use super-resolution STED microscopy to look at the receptor organisation and study the dynamics of the using fluorescence recovery after photobleaching (FRAP) and fluorescence correlation spectroscopy (FCS).