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Supat Thongjuea


Computational Biologist

My research focuses on a rare population of hematopoietic stem cells (HSCs) which is necessary and sufficient for replenishing all mature blood cells for a person’s lifetime. Studying the heterogeneity and molecular functions of HSCs is essential to understand how different pools of HSCs fine-tune the dynamic process of lineage commitment to maintaining the production of normal blood cells under steady-state and stress conditions.

I mainly develop and apply statistical and computational approaches for the analysis of large-scale single-cell transcriptomes produced by different types of single-cell technologies (i.e. 10x genomics) for studying the complexity of HSCs and progenitor cell subpopulations. The aims are to identify novel HSC and progenitor cell populations in normal hematopoiesis, to discover signature genes, regulatory networks and cellular pathways that drive their heterogeneity, and to determine how perturbations to the identified regulatory networks lead to blood developmental defects and cause leukemia. In addition, I have also focused on the analysis of epigenomes and long non-coding RNAs that play a role in the cell fate decision particularly in the lineage-biased HSCs.

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