Head of Computational Biology Research Group
My group provides computing support for bioinformatics analysis at the University of Oxford. We have expertise in many aspects of bioinformatics and especially encourage collaborations that require writing custom software, bioinformatics tools and databases. I co-developed Zegami, an image analysis and visualisation platform, which is now a Oxford spin-out company. I am currently researching the use of Virtual Reality in scientific visualisation.
M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.
Cole SL. et al, (2017), JCI Insight, 2
Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia.
Mettananda S. et al, (2017), Haematologica, 102, e80 - e84
A molecular roadmap of definitive erythropoiesis from human induced pluripotent stem cells.
Razaq MA. et al, (2017), Br J Haematol, 176, 971 - 983
Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.
Clynes D. et al, (2015), Nat Commun, 6
Human induced pluripotent stem cell-derived B lymphocytes express sIgM and can be generated via a hemogenic endothelium intermediate.
French A. et al, (2015), Stem Cells Dev, 24, 1082 - 1095