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Shilpa Nagarajan

PhD


Novo Nordisk Postdoctoral Research Fellow

I completed my PhD in Physiology in 2019 at the Lipid Metabolism Lab under Dr Andrew Hoy’s supervision at the University of Sydney. My PhD project explored the role that lipid droplet proteins play in the pathogenesis of insulin resistance in hepatic steatosis. By investigating proteins predicted to be perturbed with obesity-induced hepatic insulin resistance, I have discovered a novel insulin-sensitive protein candidate involved in the regulation of lipolysis and fatty acid oxidation in the liver.

I was awarded a Novo Nordisk Postdoctoral Research Fellowship to work with Professor Leanne Hodson, Dr Katherine Pinnick and Professor Fredrik Karpe in OCDEM starting in October 2019. The project explores the relationship between intrahepatocellular lipid droplet morphology, localisation and composition and hepatic glucose output. I will be utilizing 2D and 3D cell culture models of hepatic steatosis and stable-isotope tracers in participants to better understand what impacts hepatic insulin resistance in humans. This will aid the development of more effective treatments.

Recent publications

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