Contact information
Research groups
Post-doctoral researcher position open
Currently available.
Shijie Cai
Principal Investigator
- Member of Steering Committee of Global Cholangiocarcinoma Alliance
- Doctor of Philosophy (PhD) - Gene Therapy, University of Cambridge
- Master of Philosophy (MPhil) - Paediatric Viral Respiratory Infection, University of Liverpool
- Clinical Research Fellow - Paediatric Infectious Diseases, Alder-Hey Children Hospital, University of Liverpool
- Doctor of Medicine - Tongji Medical University, China
Integrative omics analysis and target development for various cancer types
Our research interests lie in studying the molecular mechanisms of the tumour microenvironment and target development. We focus on the impact of metabolism and epigenetic regulation on crosstalk between stromal cells and tumour cells. The ongoing investigated tumours include colorectal cancer, breast cancer and cholangiocarcinoma.
GROUP MEMBERS:
Yao Jiang - Postdoctoral Researcher
Galina Boskh - DPhil student
Ann-Katrin Wesche - Visitor
Gemma Owen - DPhil student
Key publications
-
GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner.
Journal article
Wang Z. et al, (2023), Cancer Res
Recent publications
-
GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner.
Journal article
Wang Z. et al, (2023), Cancer Res
-
Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.
Journal article
Tian Y. et al, (2021), Cell Death Dis, 12
-
GTP cyclohydrolase accelerates tumor progression through interaction with angiopoietin-1 in stromal fibroblasts and activation of Tie2 on breast cancer cells
Conference paper
CAI S. et al, (2017)
-
GTP cyclohydrolase as a novel mechanism for tumour growth
Conference paper
CAI S. et al, (2017)
-
Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth.
Journal article
Chen L. et al, (2016), Oncotarget, 7, 9353 - 9367
-
Cord and cord blood-derived endothelial cells
Chapter
Watt SM. et al, (2014), Cord Blood Stem Cells Medicine, 49 - 61
-
Effect of trans10, cis12-conjugated linoleic acid on glucose consumption of insulin resistance chang liver cells
Journal article
Li C. et al, (2011), Journal of Food Biochemistry, 35, 1593 - 1602
-
Roles of tetrahydrobiopterin in promoting tumor angiogenesis.
Journal article
Chen L. et al, (2010), Am J Pathol, 177, 2671 - 2680