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Shahana Sengupta

BSc (Hons)

DPhil Student

I graduated with a BSc (hons) in Biochemistry from the University of York (2014), and spent my final year dissertation looking at the antibody responses following 'Helicobacter hepaticus' infection in a mouse model for inflammatory bowel disease. I have also done summer placement projects at both the MRC Laboratory of Molecular Biology (2010) and Babraham Institute (2013), looking at Arfaptin in Golgi function and T lymphocyte signaling in autophagy respectively. 

I started my DPhil in 2015, working under the supervision of Prof. Anna Gloyn (OCDEM) and Prof. Roger Cox (MRC Harwell). I am based at both OCDEM and MRC Harwell, working on deciphering the molecular mechanisms at Type 2 Diabetes (T2D) association signals, namely PAM and CCND2 (DiVa Consortium).  

My project will make use of both in vitro and in vivo techniques to elucidate mechanisms at these loci. It involves functional characterization of coding variants within PAM, either identified in association with T2D risk or in a patient with neonatal diabetes. In addition, I will be phenotyping a beta-cell specific mouse knockout of PAM, to elucidate the relative contributions of PAM in pancreatic beta cells versus other tissues on insulin secretion. I am also working to understand the molecular mechanism by which alleles at the CCND2 locus influence T2D risk, utilizing both in silico tools and in vitro characterization.  In my spare time I'm a keen artist, love travelling and playing piano.

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