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Sandy Chu

BSc(Hon), MRes, PhD

Postdoctoral Researcher

I obtained my BSc(Hons) in Physiology and Pharmacology at UCL in 2013. I then did my PhD at Queen Mary University of London under the supervision of Professor Adrian Hobbs, studying the physiological roles of C-type natriuretic peptide in cardiac function. After finishing my PhD I joined the laboratory of Prof. Keith Channon at the University of Oxford in 2018.

Myocardial infarction (MI) results in tens of thousands of deaths per year and is one of the major causes of heart failure. It is a complex disease that involves reperfusion injury, inflammation response and cellular repair. My research in the Channon group focuses on the role of tetrahydrobiopterin (BH4) in MI and heart failure. BH4 is an essential chemical factor involved in the production of nitric oxide (NO). The biology of NO in the cardiovascular system is well established but recent data suggests that BH4 has a much broader roles besides NO production. For example, BH4 can directly affects inflammation, cellular metabolism and mitochondrial function in numerous cell types that widely contribute to cardiovascular diseases. I employ in vitro techniques, preclinical models, together with ‘omics’ studies to understand the molecular roles of BH4 in cardiac function, with aims to develop new therapeutic targets for cardiovascular diseases.