Shahana Sengupta

BSc (hons) Biochemistry


DPhil student


In 2014, I graduated with a BSc (hons) in Biochemistry from the University of York, and spent my final year dissertation looking at the antibody responses following Helicobacter hepaticus infection in a mouse model for inflammatory bowel disease.

I started my DPhil in 2015, working under the supervision of Prof. Anna Gloyn (OCDEM) and Prof. Roger Cox (MRC Harwell). I am based both at OCDEM and MRC Harwell, working on deciphering the molecular mechanisms of PAM, a gene encoding a bifunctional enzyme that catalyses the alpha-amidation of many neuroendocrine peptides, in type 2 diabetes (T2D) risk and pancreatic beta cell dysfunction. 

My project makes use of both in vitro and in vivo techniques to elucidate mechanisms at this locus. This involves functional characterization of coding variants within PAM, either identified in association with T2D risk or in an individual with neonatal diabetes. In addition, I will be investigating the function in vivo by making use of mouse models of Pam, to explore the relative contributions of PAM in pancreatic beta cells versus other tissues on insulin secretion and glucose homeostasis.

 

Affiliations: Dept. of Biochemistry, St. Cross College