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Shahana Sengupta

DPhil student

I graduated with a BSc (hons) in Biochemistry from the University of York (2014), and spent my final year dissertation looking at the antibody responses following Helicobacter hepaticus infection in a mouse model for inflammatory bowel disease. I have also done summer placement projects at both the MRC Laboratory of Molecular Biology (2010) and Babraham Institute (2013), looking at Arfaptin in Golgi function and autophagy signaling in T lymphocytes respectively.


I started my DPhil (Biochemistry) in 2015, working under the supervision Prof. Roger Cox (MRC Harwell) and Prof. Anna Gloyn (OCDEM). I am based both at OCDEM and MRC Harwell, working on deciphering the molecular mechanisms of PAM, a gene encoding a bifunctional enzyme that catalyses the alpha-amidation of many neuroendocrine peptides, in type 2 diabetes (T2D) risk.


My project makes use of both in vitro and in vivo techniques to elucidate mechanisms at this locus. It involves functional characterization of coding variants within PAM, either identified in association with T2D risk or in an individual with neonatal diabetes. In addition, I will be phenotyping a beta-cell specific mouse knockout of Pam, to elucidate the relative contributions of PAM in pancreatic beta cells versus other tissues on insulin secretion and glucose homeostasis.


In my spare time I’m a keen artist, love travelling and playing piano.


Affiliations: Dept. of Biochemistry, St. Cross College