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Shahana Sengupta

BSc (hons) Biochemistry


DPhil student



I started my DPhil in 2015, working under the supervision of Prof. Anna Gloyn (OCDEM) and Prof. Roger Cox (MRC Harwell). My DPhil entails working on deciphering the molecular mechanisms of PAM, a gene encoding a bifunctional enzyme that catalyses the alpha-amidation of many neuroendocrine peptides, in type 2 diabetes (T2D) risk and pancreatic beta cell dysfunction. 

I am utilising both in vitro and in vivo techniques to elucidate mechanisms at this locus. This involves functional characterisation of coding variants within PAM, either identified in association with T2D risk or in an individual with neonatal diabetes.

Affiliations: Dept. of Biochemistry, St. Cross College