Contact information
robin.choudhury@cardiov.ox.ac.uk
+44 (0)1865 234664
Miss Eunice Berry
eunice.berry@cardiov.ox.ac.uk
Colleges
Robin Choudhury
MA DM FRCP
Professor of Cardiovascular Medicine
- Honorary Consultant Cardiologist
- Fellow in Biomedical Sciences, Balliol
Integrative Physiology (Systems Biology)
Overview
This translational science laboratory aims to understand how cells of the innate immune system are involved in processes of tissue homeostasis, injury and repair.
Areas of particular interest focus around: (1) understanding the role of monocytes, macrophages and neutrophils in acute myocardial infarction; myocardial regeneration vs repair and in atherosclerosis and (2) how these cells are 'programmed' e.g. by extracellular vesicles and through by genetic / epigenetic and metabolic mechanisms.
Robin Choudhury qualified in medicine at the University of Oxford with postgraduate training in London (Royal Brompton & Hammersmith) and at Mount Sinai School of Medicine, New York. He is currently Professor of Cardiovascular Medicine at the University of Oxford; Consultant Cardiologist to the John Radcliffe Hospital and Research Fellow in Biomedical Sciences at Balliol.
He is co-PI of of the NovoNordisk Foundation supported Metabolite-related inflammation and disease (MeRIAD) consortium. He serves on the Editorial Board of the Journal of the American Journal of Cardiology (Section Editor, Clinical Cardiology).
Key publications
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Inflammatory processes in cardiovascular disease: a route to targeted therapies.
Ruparelia N. et al, (2017), Nat Rev Cardiol, 14, 133 - 144
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Arterial Effects of Canakinumab in Patients With Atherosclerosis and Type 2 Diabetes or Glucose Intolerance.
Choudhury RP. et al, (2016), J Am Coll Cardiol, 68, 1769 - 1780
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Differential Gene Expression in Macrophages From Human Atherosclerotic Plaques Shows Convergence on Pathways Implicated by Genome-Wide Association Study Risk Variants.
Chai JT. et al, (2018), Arterioscler Thromb Vasc Biol, 38, 2718 - 2730
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Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics.
Cahill TJ. et al, (2017), Nat Rev Drug Discov, 16, 699 - 717
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Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair.
Simões FC. et al, (2020), Nat Commun, 11
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Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans.
Ruparelia N. et al, (2015), Eur Heart J, 36, 1923 - 1934
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Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction.
Akbar N. et al, (2017), JCI Insight, 2
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Diabetes and Metabolic Drivers of Trained Immunity: New Therapeutic Targets Beyond Glucose.
Choudhury RP. et al, (2021), Arterioscler Thromb Vasc Biol
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Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis.
Edgar L. et al, (2021), Circulation
Recent publications
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Benchmarking Photon-Counting Computed Tomography Angiography Against Invasive Assessment of Coronary Stenosis: Implications for Severely Calcified Coronaries.
Kotronias RA. et al, (2025), JACC Cardiovasc Imaging
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Impact of soluble thrombomodulin and activated protein C on dynamic hemostatic function in trauma: a focus on thrombin generation and clot lysis.
Curry NS. et al, (2025), Haematologica, 110, 414 - 424
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Emerging opportunities to target inflammation: myocardial infarction and type 2 diabetes.
Kufazvinei TTJ. et al, (2024), Cardiovasc Res, 120, 1241 - 1252
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Cardiovascular Magnetic Resonance Before Invasive Coronary Angiography in Suspected Non-ST-Segment Elevation Myocardial Infarction.
Shanmuganathan M. et al, (2024), JACC Cardiovasc Imaging, 17, 1044 - 1058