The ginkgolides are a family of terpene trilactone natural products exclusive to the Ginkgo biloba tree. Here, we present a concise synthesis of their spirotetracyclic core via a manganese(III)-mediated oxidative radical cascade. Beginning from six simple starting materials, this route enables the diastereoselective synthesis of rings A, B, D and E of the natural product in nine steps, laying the foundations for their total synthesis.
Journal article
2025-07-25T00:00:00+00:00
27
7927 - 7932
5
Molecular Structure, Ginkgolides, Stereoisomerism, Biological Products, Spiro Compounds, Ginkgo biloba, Oxidation-Reduction, Manganese, Free Radicals, Catalysis