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- Milne Group: Epigenetics and Gene Regulation in Leukaemia Research Group
My current work aims to modify gene transcription as a target for therapy in leukaemia. This focuses on understanding the control of gene transcription through epigentic modifications. My background experience is in the cellular response to DNA damage, consequently I am interested in the coupling of gene transciption with DNA repair. In the past I have used conventional cloning techniques to generate cell lines as tools for study and I am now using the latest CRIPR/Cas9 systems to provide previously unavailable cellular reagents. Within the Milne group, we use a range of cellbiology assays to study changes in leukaemic growth after inhibition of chromatin proteins. These novel therapeutic targets are undergoing further investigation.