BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.
Haythorne E. et al, (2019), Nat Commun, 10
PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.
Guida C. et al, (2019), EBioMedicine, 40, 67 - 76
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.
Vergari E. et al, (2019), Nat Commun, 10
Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.
Hastoy B. et al, (2018), Sci Rep, 8
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.
Knudsen JG. et al, (2018), Cell Metab