SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications.

Singh S., Ahmed D., Dolatshad H., Tatwavedi D., Schulze U., Sanchi A., Ryley S., Dhir A., Carpenter L., Watt SM., Roberts DJ., Abdel-Aal AM., Sayed SK., Mohamed SA., Schuh A., Vyas P., Killick S., Kotini AG., Papapetrou EP., Wiseman DH., Pellagatti A., Boultwood J.

DOI

10.1038/s41375-020-0753-9

Type

Journal article

Publication Date

2020-09-01T00:00:00+00:00

Volume

34

Pages

2525 - 2530

Total pages

5

Keywords

DNA Damage, Humans, Mutation, Myelodysplastic Syndromes, Phosphoproteins, R-Loop Structures, RNA Splicing Factors

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