Nicole Krentz is a postdoctoral research fellow at the Wellcome Centre for Human Genetics at the University of Oxford and the Robert Turner Research Associate at Green Templeton College. Nicole completed her PhD at the University of British Columbia under the supervision of Francis Lynn in 2018. Her PhD research focused on pancreas development and endocrine cell genesis using mouse embryos and human embryonic stem cell differentiation as models. In collaboration with Michael German’s lab at the UCSF, Nicole discovered that the cell cycle regulates endocrine cell development by phosphorylating the transcription factor Neurog3. In 2018, Nicole moved to Oxford and joined Anna Gloyn’s group where she is now investigating the role of diabetes associated genes in pancreas development using genome-editing in human induced pluripotent stem cell models.
Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors.
Krentz NAJ. et al, (2017), Dev Cell, 41, 129 - 142.e6
Using CRISPR-Cas9 genome editing to enhance cell based therapies for the treatment of diabetes mellitus
Krentz NAJ. and Lynn FC., (2016), Genome Editing, 127 - 147
SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models.
Xu EE. et al, (2015), Diabetologia, 58, 1013 - 1023
A regulatory network controls nephrocan expression and midgut patterning.
Hou J. et al, (2014), Development, 141, 3772 - 3781
TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm.
Krentz NAJ. et al, (2014), PLoS One, 9