Nicole Krentz is a postdoctoral research fellow at the Wellcome Centre for Human Genetics at the University of Oxford and the Robert Turner Research Associate at Green Templeton College. Nicole completed her PhD at the University of British Columbia under the supervision of Francis Lynn in 2018. Her PhD research focused on pancreas development and endocrine cell genesis using mouse embryos and human embryonic stem cell differentiation as models. In collaboration with Michael German’s lab at the UCSF, Nicole discovered that the cell cycle regulates endocrine cell development by phosphorylating the transcription factor Neurog3. In 2018, Nicole moved to Oxford and joined Anna Gloyn’s group where she is now investigating the role of diabetes associated genes in pancreas development using genome-editing in human induced pluripotent stem cell models.
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
Dwivedi OP. et al, (2019), Nat Genet
TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation.
Campbell SA. et al, (2019), Cell Rep, 28, 1830 - 1844.e6
Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors.
Krentz NAJ. et al, (2018), Stem Cell Reports, 11, 1551 - 1564
Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors.
Krentz NAJ. et al, (2017), Dev Cell, 41, 129 - 142.e6
Manipulating Kras signalling alters endocrine differentiation by changing cell cycle length during mouse embryonic pancreas development
Krentz NAJ. et al, (2016), DIABETOLOGIA, 59, S200 - S200