Nicolas Bery
Postdoctoral Research Scientist
I completed my MSc degrees in Biochemistry and Oncology at the INSA Toulouse and at the Paul Sabatier University in Toulouse, France. I started my PhD. in 2010 in Professor Gilles Favre's group in Toulouse. My PhD focused on two linked parts: the characterisation of a universal synthetic humanised nanobody library and the establishment of a cell-based screening method that reveals functional intracellular antibodies (intrabodies) using the fusion of a Fbox domain with nanobodies. Applying this screen, we isolated an Fbox-intrabody able to degrade selectively the small GTPase RHOB-GTP. I was awarded my PhD in 2014 and I continued my work on this project until I joined Professor Rabbitts' group in April 2015. My work here focuses on the development of cell-based assays for the screening and the characterisation of small molecule inhibitors of LMO2 / VH and RAS / effector protein-protein interactions.
Recent publications
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Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Journal article
Guillard S. et al, (2017), Nat Commun, 8
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Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells.
Journal article
Jullien D. et al, (2016), Development, 143
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Single domain antibodies with VH hallmarks are positively selected during panning of llama (Lama glama) naïve libraries.
Journal article
Monegal A. et al, (2012), Dev Comp Immunol, 36, 150 - 156
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Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells.
Journal article
Jullien D. et al, J Cell Sci, 129, 2673 - 2683
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NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies.
Journal article
Moutel S. et al, Elife, 5