Nicolas Bery

I completed my MSc degrees in Biochemistry and Oncology at the INSA Toulouse and at the Paul Sabatier University in Toulouse, France. I started my PhD. in 2010 in Professor Gilles Favre's group in Toulouse. My PhD focused on two linked parts: the characterisation of a universal synthetic humanised nanobody library and the establishment of a cell-based screening method that reveals functional intracellular antibodies (intrabodies) using the fusion of a Fbox domain with nanobodies. Applying this screen, we isolated an Fbox-intrabody able to degrade selectively the small GTPase RHOB-GTP.  I was awarded my PhD in 2014 and I continued my work on this project until I joined Professor Rabbitts' group in April 2015. My work here focuses on the development of cell-based assays for the screening and the characterisation of small molecule inhibitors of LMO2 / VH and RAS / effector protein-protein interactions.