Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Nathalie Sakakini


Postdoctoral researcher

After completing my PhD at Aix-Marseille University in France, studying the molecular mechanisms sustaining cell proliferation in human glioblastoma stem cells, I joined the laboratory of Professor Paresh Vyas (Molecular Haematology Unit, Weatherall Institute of Molecular Medicine) in 2015.

 My research is focused on abnormal differentiation of megakaryocytes in Down-Syndrome children with Transient Abnormal Myelopoiesis (TAM).  TAM constitutes a pre-leukemic stage, which leads in ~20% of the cases to a megakaryoblastic leukemia (AMKL).  It is characterised by an acquired mutation in GATA1, a transcription factor involved in erythroid and megakaryocytic commitment. The mutation produces a shorter isoform, called GATA1s, lacking the N-terminal activation domain. Unravelling GATA1s functions is fundamental to gain insights on its contribution on altered hematopoiesis. It is also a prerequisite for understanding the cooperation between GATA1s and additional mutations leading to AMKL. 

False False