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Nathalie Sakakini

PhD


Postdoctoral researcher

After completing my PhD at Aix-Marseille University in France, studying the molecular mechanisms sustaining cell proliferation in human glioblastoma stem cells, I joined the laboratory of Professor Paresh Vyas (Molecular Haematology Unit, Weatherall Institute of Molecular Medicine) in 2015.

 My research is focused on abnormal differentiation of megakaryocytes in Down-Syndrome children with Transient Abnormal Myelopoiesis (TAM).  TAM constitutes a pre-leukemic stage, which leads in ~20% of the cases to a megakaryoblastic leukemia (AMKL).  It is characterised by an acquired mutation in GATA1, a transcription factor involved in erythroid and megakaryocytic commitment. The mutation produces a shorter isoform, called GATA1s, lacking the N-terminal activation domain. Unravelling GATA1s functions is fundamental to gain insights on its contribution on altered hematopoiesis. It is also a prerequisite for understanding the cooperation between GATA1s and additional mutations leading to AMKL. 

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