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Michael Mackley

BSc (Hons)

DPhil Student

I am a postgraduate student, reading for a DPhil on a Rhodes Scholarship and RDM Scholarship. I am working under the supervision of Prof Hugh Watkins and Dr Elizabeth Ormondroyd (Cardiovascular Medicine) and Prof Michael Parker (Ethox Centre, Nuffield Department of Population Health).

My research interests are in inherited disease and the realisation of genomic medicine in clinical practice. I am particularly interested in the rapid translation of whole-genome sequencing into the clinic, and the need to explore the impact and implications that such technologies have for patient care and society at-large.  More specifically, my doctoral work explores the issue of cardiac secondary findings in whole-genome sequencing: findings that have potential health benefits, but are unrelated to the indication for which the testing was ordered. These findings, which can alert physicians to potentially lethal conditions for which treatment is available, present novel clinical and ethical scenarios. Using a mix of qualitative data (including semi-structured interviews) as well as quantitative data (including clinical and computational work) I am exploring issues around secondary findings, ranging from the clinical utility of secondary findings to how they affect individual patients.