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- Nerlov Group: Hematopoietic Stem Cell Genetics Research Group
I am a DPhil (PhD) student in Prof Claus Nerlov’ lab in the MRC Molecular Haematology Unit at the Weatherall Institute of Molecular Medicine (WIMM). My work explore human HSC heterogeneity, its role in ageing of the human hematopoietic system, and identify gene signatures and surface markers that allow hHSC subsets to be idenfied.
The human hematopoietic stem cell is the basis for the most common stem cell based therapy in clinical practice, namely bone marrow transplantation. However, hHSC remains poorly described, limiting our ability to evaluate the quality of donor cell preparations, including the number of reconstituting hHSCS they contain and their capacity to rapidly reconstitute the cell types (neutrophils, platelets) critical for patient recovery.
My project aims ;
To simultaneously characterize hHSC transcriptomes and lineage output by combining barcoding during hHSC xenografting
- To identify and purify lineage biased hHSCs in young adult and aged bone marrow
Improved understanding of human hematopoietic stem cell biology will contribute to the treatment of both congenital and acquired blood disorders. In particular, better definition of hHSCs will facilitate efforts to genome edit hHSCs in congenital blood disorders, and improve donor selection for BMT.