Megat Abd Hamid
DPhil; B.Biotech (Hons)
My research focus is on understanding the characteristics and underlying mechanisms of co-inhibitory and co-stimulatory receptors on cancer-specific cytotoxic T cells and how this could be manipulated for future cancer immunotherapies. Primarily, I am looking into:
1. Distribution of HLA-E and its inhibitory receptors CD94/NKG2a and exploitation of this machinery by cancer to inhibit anti-tumor T cell responses.
2. Importance of self-sustain, highly energetic CD103+ tissue resident memory T cells in anti-tumor responses
3. Epigenetic regulation of effector cytokine responses of cancer-specific T cells.